Definition of depopulate in English:

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depopulate

Pronunciation: /dēˈpäpyəˌlāt/

verb

[with object]
Substantially reduce the population of (an area): the disease could depopulate a city the size of New Haven
More example sentences
  • The valleys have not lost their character but agricultural and industrial changes have depopulated some areas and opened others to an influx of lowlanders seeking holiday and retirement homes.
  • For much of the period 1920-1980, large parts of the northern coastal area were effectively depopulated.
  • About 4,000 villages have been burnt and razed to the ground in an attempt to depopulate the area.

Origin

Mid 16th century (in the sense 'ravage, lay waste'): from Latin depopulat- 'ravaged', from the verb depopulari, from de- 'completely' + populari 'lay waste' (from populus 'people').

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