Definition of hypermutable in English:

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Pronunciation: /ˌhīpərˈmyo͞odəb(ə)l/


Of or in a state in which mutation is abnormally frequent.
Example sentences
  • After 60 cycles of single colony isolation, close to 30% of the lineages have a mutation at this hypermutable site.
  • As predicted by the fact that microsatellites are hypermutable, many flanking-sequence variants were associated with multiple repeat alleles.
  • The situation of recurrent mutation is especially likely for a C / T polymorphism at the hypermutable CpG dinucleotides.



Pronunciation: /-myo͞oˈtāSHən/
Example sentences
  • For example, somatic hypermutation of Ig genes is used to generate antibodies with increased antigen affinity.
  • Among the progeny, a variable proportion suffer hypermutation (C-to-T transitions) of both copies of the gene.
  • The corresponding near-neighbors had to be removed because not all putative CG tandems are generated by CG hypermutation.

For editors and proofreaders

Syllabification: hy·per·mu·ta·ble

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