Modifying the force or speed of contraction of muscles.
- A direct positive inotropic effect and an increase in the refractory period also have been postulated as possible antiarrhythmia mechanisms of spironolactone.
- It has therapeutic use in congestive heart failure and edema, having a positive inotropic effect on cardiac muscle.
- It seems that the capability for carefully manipulating and combining agents for use in both inotropic and vasodilator actions has improved our ability to manage previously refractory patients.
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