Definition of ligase in English:


Syllabification: li·gase
Pronunciation: /ˈlīˌgās, -ˌgāz


  • An enzyme that brings about ligation of DNA or another substance.
    More example sentences
    • These DNA-binding proteins include polymerases, helicases, nucleases, isomerases, ligases, histones, and others.
    • After all, in nature we can and do observe bacteria using restriction endonucleases and ligases to cut DNA.
    • This study shows that in a competition between the two enzymes, DNA ligase trumps the flap endonuclease in capturing bubbles and creating expanded tracts.


1960s: from Latin ligare 'to bind' + -ase.

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