Definition of ligation in English:

Share this entry


Pronunciation: /līˈɡāSHən/


1The surgical procedure of closing off a blood vessel or other duct or tube in the body by means of a ligature or clip.
Example sentences
  • Failure to recognize such aberrant ductal anatomy may lead to potential ligation of ducts during surgery.
  • Treatments vary from radiological ablation to surgical ligation of the varicocele, although most urologists reserve the radiological approach for the rare surgical failures.
  • One hospital transfer is accounted to each of the following procedures: circumcision, cystoscopy, hemorrhoid ligation and vasectomy reversal.
2 Biochemistry The joining of two DNA strands or other molecules by a phosphate ester linkage.
Example sentences
  • A mechanism leading to tandem sequence duplication may involve DNA damage followed by DNA synthesis, strand displacement, and ligation.
  • The ligation reactions were used as template DNA for one of the following methods.
  • The cut DNAs were ligated at low concentrations, to encourage intramolecular ligation reactions.


Late Middle English: from late Latin ligatio(n-), from the verb ligare (see ligate).

Share this entry

What do you find interesting about this word or phrase?

Comments that don't adhere to our Community Guidelines may be moderated or removed.