Definition of ligation in English:


Syllabification: li·ga·tion
Pronunciation: /līˈɡāSHən


1The surgical procedure of closing off a blood vessel or other duct or tube in the body by means of a ligature or clip.
More example sentences
  • Failure to recognize such aberrant ductal anatomy may lead to potential ligation of ducts during surgery.
  • Treatments vary from radiological ablation to surgical ligation of the varicocele, although most urologists reserve the radiological approach for the rare surgical failures.
  • One hospital transfer is accounted to each of the following procedures: circumcision, cystoscopy, hemorrhoid ligation and vasectomy reversal.
2 Biochemistry The joining of two DNA strands or other molecules by a phosphate ester linkage.
More example sentences
  • A mechanism leading to tandem sequence duplication may involve DNA damage followed by DNA synthesis, strand displacement, and ligation.
  • The ligation reactions were used as template DNA for one of the following methods.
  • The cut DNAs were ligated at low concentrations, to encourage intramolecular ligation reactions.


late Middle English: from late Latin ligatio(n-), from the verb ligare (see ligate).

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