Any of a class of antibiotics containing a lactone ring, of which the first and best known is erythromycin.
- As with other currently available fluoroquinolone and macrolide antibiotics, QTc interval prolongation has been linked to the use of telithromycin.
- Trials investigating the role of macrolide antibiotic therapy in patients with acute coronary syndromes are inconclusive.
- If antibiotics are required, one that is active against gram-positive organisms such as penicillinase-resistant penicillins, cephalosporins, macrolides, or fluoroquinolones should be chosen.
Mid 20th century: from macro- + l(actone) + -ide.
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