A large, abnormally developed red blood cell typical of certain forms of anemia, associated with a deficiency of folic acid or of vitamin B12.
- Enlarged red cells, called megaloblasts, are caused by vitamin B12 deficiency and folate deficiency.
- Ehrlich distinguished 3 types of granulated white blood cells, as well as normoblasts, megaloblasts, and leukemic cells.
- Enlarged red cells derived from megaloblasts are a consequence of a deficiency of vitamin B12 or folic acid.
- Example sentences
- Iron-deficiency anaemia and megaloblastic anaemia can occur during pregnancy.
- The classic affected patient who presents with neuropathy and megaloblastic anemia likely represents the minority of subjects with cobalamin deficiency.
- Folate and vitamin D deficiency may necessitate vitamin supplementations and, if uncorrected, leads to megaloblastic anemia.
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