Share this entry
methotrexate Syllabification: meth·o·trex·ate
Pronunciation: /ˌmeTHəˈtreksāt/

Definition of methotrexate in English:


A synthetic compound that interferes with cell growth and is used to treat leukemia and other forms of cancer.
  • Alternative name: 4-amino-10-methylfolic acid; chemical formula: C20H22N8O5
Example sentences
  • Cancer drugs used for primary bone cancer include methotrexate, doxorubicin, and cisplatin.
  • Treatment may include systemic steroids, intralesional steroid injection, antimalarials, or methotrexate.
  • Antimalarial drugs or immune response modifiers like methotrexate can reduce steroid dose and side effects.


1950s: from meth- (denoting a substance containing methyl groups) + elements of unknown origin.

Definition of methotrexate in:
Share this entry

What do you find interesting about this word or phrase?

Comments that don't adhere to our Community Guidelines may be moderated or removed.

Subscribe to remove ads and access premium resources