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1a minute portion of matter:tiny particles of dust [with negative] the least possible amount:he agrees without hearing the least particle of evidence Mathematics a hypothetical object having mass but no physical size. 2 Grammar a minor function word that has comparatively little meaning and does not inflect, in particular. (in English) any of the class of words such as in, up, off, over, used with verbs to make phrasal verbs. (in ancient Greek) any of the class of words such as de and ge, used for contrast and emphasis.