Definition of pleiotropy in English:

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Pronunciation: /plīˈätrəpē/


The production by a single gene of two or more apparently unrelated effects.
Example sentences
  • If gene effects on the trait and fitness are correlated due to pleiotropy, genes of large effect on the trait will remain at much lower frequencies.
  • At the level of populations, the scaling of mutational effects with pleiotropy can be addressed via the neutral theory of molecular evolution.
  • These studies demonstrated that performance and preference of host-plant use may be genetically associated by linkage or pleiotropy, and evolve as correlated traits.



Pronunciation: /ˌplīəˈtrōpik/ Pronunciation: /-ˈträpik/
Example sentences
  • Similarly, mutations within the Drosophila CBP homolog have wide-ranging pleiotropic phenotypes.
  • Many semidwarf mutants have pleiotropic effects on traits other than culm length.
  • Many mutants died or showed pleiotropic defects casting doubt on the specificity of their retinal phenotype and were not included in this report.


Pronunciation: /ˌplīˈätrəˌpizəm/
Example sentences
  • If the majority of mutations have large negative impacts on fitness, pleiotropism will act to increase their selective effects in nature.
  • Pleiotropism is a hallmark of cytokines and growth factors; yet, the underlying mechanisms are not clearly understood.
  • The gene exhibited pleiotropism by influencing not only oleate and linoleate, but also levels of palmitate, gadoleate, and total saturated fatty acids.


1930s: from Greek pleiōn 'more' + tropē 'turning'.

For editors and proofreaders

Syllabification: plei·ot·ro·py

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