Definition of proband in English:


Syllabification: pro·band
Pronunciation: /ˈprōˌband, prōˈband


  • A person serving as the starting point for the genetic study of a family (used especially in medicine and psychiatry).
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    • Furthermore, all these approaches are unable to handle trios with missing genotypic information on the proband and these families are typically excluded from the analysis.
    • A genetic basis to the disorder is borne out by risk increasing with genetic proximity to the proband.
    • Most data sets utilized in the study of hereditary diseases are constructed around probands, making correction for ascertainment bias necessary; this set of data is no exception.


1920s: from Latin probandus 'to be proved', gerundive of probare 'to test'.

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