Definition of procaine in English:

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Pronunciation: /ˈprōˌkān/


A synthetic compound derived from benzoic acid, used as a local anesthetic, especially in dentistry.
Example sentences
  • Dr. Persons says that chloroprocaine or procaine (Procaine, Novocain) should be safe in patients with true ‘amide’ allergy because they are esters.
  • In comparative studies, dry needling was found to be as effective as injecting an anesthetic solution such as procaine or lidocaine (Xylocaine).
  • History of an allergy to an ester anesthetic such as procaine is not a contraindication to the use of lidocaine, because they are chemically different, and cross-reaction is rare.


Early 20th century: from pro-1 (denoting substitution) + -caine (from cocaine).

For editors and proofreaders

Syllabification: pro·caine

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