A substance produced by the pancreas that is converted to insulin.
- Following cleavage of the 24 amino acid signal peptide the protein folds into proinsulin.
- Unlike the single chain precursor of insulin, proinsulin, this new construct retains up to 40 per cent of insulin activity.
- The processing of proinsulin to insulin within the secretory granules of the Golgi complex is dependent on critical levels of pH as well as ATP.
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