Definition of sonicate in English:


Syllabification: son·i·cate
Pronunciation: /ˈsänikāt


[with object] (usually be sonicated)
  • Subject (a biological sample) to ultrasonic vibration so as to fragment the cells, macromolecules, and membranes.
    More example sentences
    • The sample was sonicated to clarity in a sonication bath (Ultrawave).
    • The samples were sonicated for 30 min, followed by centrifugation and overnight incubation at 65°C as described above.
    • The samples were sonicated for 12 sec and cell number was analyzed using a Coulter counter.


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  • A biological sample that has been sonicated.
    More example sentences
    • Finally, the sonicate in the third cuvette was additionally treated with DNase for another 1 h at 25 deg C, then Cyan 40 was added and the emission spectrum was recorded.
    • The sonicate was cleared by centrifugation at 12,000 g for 30 minutes at 4°C.
    • The sonicate was cleared by microcentrifugation for 5 min at 4° and mixed with the anti-HA.11 antibody coupled to Sepharose beads (prewashed three times with lysis buffer).


1950s: from sonic + -ate2.

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