Definition of spironolactone in English:


Syllabification: spi·ro·no·lac·tone
Pronunciation: /ˌspīrənōˈlaktōn


  • A steroid derivative that is an aldosterone antagonist, which promotes sodium excretion and is used in the treatment of certain types of edema and hypertension.
    • Chemical formula: C24H32O4S
    More example sentences
    • For example, ACE inhibitors, beta-blockers, ARBs, spironolactone and digoxin are probably not necessary in all patients.
    • Pharmacologic agents used have included hydrochlorothiazide, spironolactone, furosemide, propranolol, or hydralazine.
    • We restricted our analyses to loop diuretics, angiotensin converting enzyme inhibitors, blockers, spironolactone, and digoxin.


1960s: from spiro-1 ( sense 2) + lactone, with the insertion of -one.

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