Definition of substituent in English:

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Pronunciation: /ˌsəbˈstiCHəwənt/


An atom or group of atoms taking the place of another atom or group or occupying a specified position in a molecule.
Example sentences
  • In an interstitial solid solution, substituent atoms or ions are added to void spaces (interstitial sites) between normal atomic sites.
  • Under rigorous conditions benzene will undergo substitution for one of its hydrogen substituents, by a process called electrophilic aromatic substitution.
  • Any groups attached to the main chain are called substituents, they are there in place of hydrogen atoms.


Late 19th century: from Latin substituent- 'standing in place of', from the verb substituere (see substitute).

For editors and proofreaders

Syllabification: sub·stit·u·ent

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