Definition of Syracuse in English:

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1ˈsīrəˌkyo͞oz A port on the eastern coast of Sicily; population 125,000. Italian name Siracusa.
2ˈsirəˌkyo͞os A city in New York, southeast of Lake Ontario; population 138,068 (est. 2008). The site of salt springs, it was an important center of salt production during the 19th century.
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