A synthetic drug used in Alzheimer’s disease to inhibit the breakdown of acetylcholine by cholinesterase and thereby enhance neurological function.
- The cholinesterase inhibitor tacrine is used rarely because of potential liver toxicity and the need for frequent laboratory monitoring.
- These effects are comparable to those of the drug tacrine, which is prescribed for Alzheimer's disease.
- The pharmacologic characteristics and side effects of tacrine make it a second-line agent.
1960s: from t(etra-) + acr(id)ine.
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