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titrate

Syllabification: ti·trate
Pronunciation: /ˈtīˌtrāt/

Definition of titrate in English:

verb

[with object] Chemistry
1Ascertain the amount of a constituent in (a solution) by measuring the volume of a known concentration of reagent required to complete a reaction with it, typically using an indicator.
Example sentences
  • To determine the exact concentration, titrating the hydrochloric acid against a solution of base, for example sodium hydroxide, would be appropriate.
  • Aliquots of the peptide solution were titrated to the micelle solution to reach a peptide-to-micelle molar ratio of 1: 220.
  • This solution was titrated with the HSA fragment by adding small amounts of an ~ 0.3 mM protein solution in the aqueous buffer and recording the spectrum after incubation for a few minutes after each addition.
1.1 Medicine Continuously measure and adjust the balance of (a physiological function or drug dosage).
Example sentences
  • In general, high doses of steroids are required, but the dosage is titrated against the response and kept to the lowest effective dose, given for as short a time as possible.
  • Symptoms include abdominal discomfort, metallic taste, nausea, and diarrhea; these effects are generally transient and can be minimized by taking the drug with meals and titrating the dose slowly.
  • The initial dose of ritodrine was 50 mg per minute, and then the dosage was titrated to contractions.

Origin

late 19th century: from French titrer (from titre in the sense 'fineness of alloyed gold or silver') + -ate3.

Derivatives

titratable

1
adjective
Example sentences
  • The relationship between titratable acidity and malic acid was less obvious.
  • The sign and magnitude of the pK a shift of a particular titratable group is determined by the free energy to transfer it into the low-dielectric protein cavity, and by its interactions with polar residues in the protein.
  • The only extra hydrogen bond that is formed involving titratable residues is between OG1 and OE2.

titration

2
Pronunciation: /ˌtīˈtrāSHən/
noun
Example sentences
  • So if Plotkin is correct when he says that the titration was done in Philadelphia, this would mean that the vaccine fed in Africa was of unknown titre.
  • The titration was done in Philadelphia and Courtois was told to dilute the material sixty-fold in order to reach the desired dose.
  • The titrations were performed with various concentrations of TFE, SDS, and DPC.

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