An enzyme that alters the supercoiled form of a DNA molecule.
- Taken together, these results indicate that the overexpression of the topoisomerase I gene causes DNA damage that is lethal only in the scaA - background.
- Among the genes affected by supercoiling are the topoisomerase genes.
- The clastogenicity of topoisomerase inhibitors is believed to result from the transient stabilization of the topoisomerase enzyme with DNA during the catalytic cycle.
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