Activation of a gene at one locus by the presence of a particular gene at another locus, typically following infection by a virus.
- The timing of these events is complex and it should be noted that the transactivation of stress-inducible genes is not fully understood even in model systems.
- These injurious substances have been reported to activate EGFR through direct ligand-mediated activation, or via transactivation.
- In mouse pituitary gonadotrope cells, MMP2 and MMP9 can mediate EGFR transactivation.
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