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transdifferentiation Syllabification: trans·dif·fer·en·ti·a·tion
Pronunciation: /tranzˌdifəˌrenSHēˈāSHən/ /trans-/

Definition of transdifferentiation in English:


The rare natural transformation of cells other than stem cells into a different cell type.
Example sentences
  • Another possibility is to replace the missing function by causing transdifferentiation of existing cells.
  • Further scrutiny has also thrown cold water on many of the transdifferentiation claims for other types of adult stem cells.
  • Histology, immunohistochemistry, and ultrastructure were highly suggestive of transdifferentiation from cardiac muscle to adipose tissue.


Pronunciation: /-SHēˌāt/
[no object]
Example sentences
  • This plasticity concept - the ability of bone marrow cell to transdifferentiate into heart muscle cell - is supported by experimental and clinical data.
  • When we over-expressed Math1 in non-sensory cells of the mature cochlea, however, we found that it causes them to transdifferentiate or change their personality to become hair cells.
  • Primordial germ cells that have been labeled using horseradish peroxidase or radioactive thymidine do not transdifferentiate, and very few transplanted cells persist outside of the gonads.
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