Definition of Philadelphia chromosome in English:

Philadelphia chromosome

Line breaks: Phila|del¦phia chromo|some


  • An abnormal small chromosome sometimes found in the leucocytes of leukaemia patients.
    More example sentences
    • The malignant transformation results from a reciprocal translocation between chromosomes 9 and 22, producing a short chromosome known as the Philadelphia chromosome.
    • CML is caused by the breakage and swapping of chromosomes 9 and 22, which results in a shortened chromosome called the Philadelphia chromosome.
    • CML is caused by the errant swapping of genetic material in bone marrow stem cells that produces an abnormality called the Philadelphia chromosome.

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