An inherited metabolic disorder in which certain lipids accumulate in the brain, causing spasticity and death in childhood.
More example sentences
- Tay-Sachs disease occurs when the body lacks hexosaminidase A, a protein that helps break down a chemical found in nerve tissue called gangliosides.
early 20th century: from the names of Warren Tay (1843–1927), English ophthalmologist, and Bernard Sachs (1858–1944), American neurologist, who described it in 1881 and 1887 respectively.
Definition of Tay–Sachs disease in:
- The US English dictionary