Definition of antagonist in English:


Line breaks: an|tag¦on|ist
Pronunciation: /anˈtaɡ(ə)nɪst


1A person who actively opposes or is hostile to someone or something; an adversary: the woman was forcing her antagonist’s face into the mud
More example sentences
  • Most of these countries, of course, are traditional adversaries or antagonists.
  • It also means that copyright gives no one the exclusive right to tell stories about archaeologists in search of artifacts hidden in snake-infested caves while simultaneously confronting dangerous human antagonists.
  • They wander off on their own, they blow up a poacher's shack for no apparent reason, and they attempt to confront their wily antagonists head on.
(antagonists)opposition, competition, the other side
rare corrival
2 Biochemistry A substance which interferes with or inhibits the physiological action of another: LSD is a serotonin antagonist Compare with agonist.
More example sentences
  • Progress has been made in the development of new anti-emetic drugs, particularly the serotonin antagonists which are potent inhibitors of chemotherapy-induced vomiting.
  • It is also an effective antagonist or inhibitor of cortisol, a stress hormone that maintains the integrity of the circulatory system.
  • The use of selective serotonin antagonists for early-onset alcohol dependence also has been investigated, with positive results.
3 Anatomy A muscle whose action counteracts that of another specified muscle. Compare with agonist.
More example sentences
  • The anterior tibialis muscle was chosen because of its function as an antagonist to the peroneal muscles.
  • This can be studied by transposing the innervation of a muscle to its antagonist, or by transposing one of its tendons to the opposite side of a joint, such that the mechanical action of the muscle is reversed.
  • Moving through a complete range of motion will strengthen the agonist and stretch the antagonist muscle.


late 16th century: from French antagoniste or late Latin antagonista, from Greek antagōnistēs, from antagōnizesthai 'struggle against' (see antagonize).

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Pronunciation: dəˈmôrəˌlīz
cause (someone) to lose confidence or hope; dispirit