Definition of dedifferentiate in English:

dedifferentiate

Line breaks: de|dif¦fer|en|ti¦ate
Pronunciation: /ˌdiːdɪfəˈrɛnʃɪeɪt
 
/

verb

[no object] Biology
(Of a cell or tissue) undergo a reversal of differentiation and lose specialized characteristics: some types of human cells dedifferentiate in culture, becoming primitive, unspecialized cells
More example sentences
  • For example, they found that the proliferating cells dedifferentiated, meaning they temporarily lost the characteristics of mature heart muscle cells and reverted to a more fetal type of proliferating cell.
  • By manipulating niche signals, they could make the stem cells differentiate, then dedifferentiate again.
  • The search for compounds to differentiate and dedifferentiate (specialize and despecialize) stem cells is accelerating due to advances in biotechnology for growing and screening cells.

Derivatives

dedifferentiation

noun
More example sentences
  • This probably reflects the presence of stem cells in the nail bud rather than cell dedifferentiation.
  • Our case could be an example of such a dedifferentiation.
  • In the presented tumor, there was no indication for dedifferentiation.

Definition of dedifferentiate in:

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