verb[no object] Biology
- (Of a cell or tissue) undergo a reversal of differentiation and lose specialized characteristics: some types of human cells dedifferentiate in culture, becoming primitive, unspecialized cellsMore example sentences
- For example, they found that the proliferating cells dedifferentiated, meaning they temporarily lost the characteristics of mature heart muscle cells and reverted to a more fetal type of proliferating cell.
- By manipulating niche signals, they could make the stem cells differentiate, then dedifferentiate again.
- The search for compounds to differentiate and dedifferentiate (specialize and despecialize) stem cells is accelerating due to advances in biotechnology for growing and screening cells.
- More example sentences
- This probably reflects the presence of stem cells in the nail bud rather than cell dedifferentiation.
- Our case could be an example of such a dedifferentiation.
- In the presented tumor, there was no indication for dedifferentiation.
More definitions of dedifferentiateDefinition of dedifferentiate in:
- The US English dictionary