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degranulate

Line breaks: de|granu|late
Pronunciation: /diːˈɡranjʊleɪt
 
/

Definition of degranulate in English:

verb

[no object] Physiology
(Of a cell) lose or release granules of a substance, typically as part of an immune reaction: the eosinophils degranulate, releasing the toxic contents of the granules
More example sentences
  • When mast cells degranulate they release tryptase, in addition to histamine and prostaglandins.
  • We found corroborative evidence that neutrophils are stimulated to degranulate and produce reactive oxidants in the airways of children with Cystic Fibrosis.
  • IL - 8 also activates neutrophils to degranulate and cause tissue damage.

Derivatives

degranulation

1
noun
Example sentences
  • Mast cell degranulation releases vasoactive substances, including histamine, which sustain the reaction by depositing additional immune complexes.
  • The ‘itch-scratch’ cycle induces mast cell degranulation and cytokines that may respond to antihistamines.
  • The data from guinea pigs were confirmed in the human system; IL - 8-activated neutrophils stimulated degranulation, and this was inhibited by elastase inhibitors.

Definition of degranulate in:

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