Definition of hypotonic in English:

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Pronunciation: /ˌhʌɪpə(ʊ)ˈtɒnɪk/


1 Biology Having a lower osmotic pressure than a particular fluid, typically a body fluid or intracellular fluid.
Example sentences
  • Thus, the photodamaged lysosomes and the normal ones will suffer the same level of osmotic stress in the same hypotonic sucrose medium.
  • At the end of the culture period cells were harvested, exposed to a hypotonic solution and fixed in methanol/acetic acid.
  • After 15 min five drops of methanol/acetic acid were added to the hypotonic solution to begin cell fixation.
2 Physiology Of or in a state of abnormally low muscle tone.
Example sentences
  • The infant with botulism becomes progressively weak, hypotonic and hyporeflexic, showing bulbar and spinal nerve abnormalities.
  • Cerebral palsy takes the form of a hypotonic tetraplegia when the child has a mobility problem but with floppy muscles.
  • On arrival, at 3 hours of age, he was hypotonic with tonic seizures of the upper extremities and bilaterally fixed, dilated pupils.



Example sentences
  • For this reason, extensive efforts have been devoted toward elucidating the mechanisms of REM sleep-related upper airway hypotonia.
  • The classic clinical features include constipation, cranial nerve abnormalities, hypotonia, hyporeflexia and respiratory difficulties.
  • Additional symptoms of chronic carnitine deficiency can include hypoglycemia, progressive myasthenia, hypotonia, or lethargy.


Example sentences
  • We investigated the effects of hyper- and hypotonicity on ion transport processes.
  • With this knowledge, the effects of hypotonicity were assessed by comparing the responses of an isotonic to a hypotonic solution.
  • Hyponatremia is most commonly associated with states of hypotonicity; however, it can also occur in states of normal or high osmolarity.
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