noun[mass noun] chiefly Anatomy & Biology
1The action or process of being turned inside out or folded back on itself to form a cavity or pouch.
- This indicates a level of plasma membrane invagination comparable with mammalian skeletal muscle.
- In the chick embryo, for example, the ectoderm initially expresses L-CAM; during neural plate invagination, however, L-CAM expression is replaced by that of N-cadherin.
- Catheters with multiple side holes on several planes are less likely to cause invagination of airway mucosa into the catheter than those with single side or end holes.
1.1 [count noun] A cavity or pouch so formed.
- Intranuclear cytoplasmic invaginations, similar to that seen in non-neoplastic hepatocytes (or in metastatic melanoma) are also frequent.
- These invaginations represent placental outgrowths and they extend towards the centre, enclosing the central hole into a triangular slit.
- As is typical, many of the latter showed reactive changes, such as large, variably sized nuclei; intranuclear invaginations; and multinucleation.
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