Definition of ligase in English:

Share this entry


Pronunciation: /ˈlɪɡeɪz/


An enzyme which brings about ligation of DNA or another substance.
Example sentences
  • These DNA-binding proteins include polymerases, helicases, nucleases, isomerases, ligases, histones, and others.
  • After all, in nature we can and do observe bacteria using restriction endonucleases and ligases to cut DNA.
  • This study shows that in a competition between the two enzymes, DNA ligase trumps the flap endonuclease in capturing bubbles and creating expanded tracts.


1960s: from Latin ligare 'to bind' + -ase.

For editors and proofreaders

Line breaks: lig¦ase

Share this entry

What do you find interesting about this word or phrase?

Comments that don't adhere to our Community Guidelines may be moderated or removed.