Definition of preclinical in English:


Line breaks: pre|clin¦ic¦al
Pronunciation: /priːˈklɪnɪk(ə)l


  • 1Relating to or denoting the first, chiefly theoretical, stage of a medical education: preclinical students
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    • Medical students with high preclinical and clinical grade point averages were, surprisingly, more likely to express an external orientation.
    • Between 1991 and 1995, some students were sent for preclinical training in Australia and South Africa as well as Britain.
    • Today, gross anatomy is taught in a preclinical dissection course for second year medical students.
  • 2Relating to or denoting the stage in a disease prior to the appearance of symptoms that make a diagnosis possible: preclinical muscular dystrophy
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    • Improved understanding of this illness during the slow progression from preclinical to moderate disease would aid the development of strategies for primary and secondary prevention.
    • Diseases with long preclinical phases are more likely to be detected by screening.
    • Mercury is neurotoxic, and even in people with low level chronic exposure, subtle preclinical effects on symptoms, mood, motor function, and cognition have been identified.
  • 3Relating to or denoting the stage of drug testing that precedes the clinical stage: preclinical trials
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    • A number of such vectors are currently being developed and tested in preclinical and early phase clinical trials.
    • Several drugs are currently under preclinical and early phase clinical study.
    • The efficacy and safety of some of the new vaccine candidates have been evaluated and proven in human preclinical / clinical trials.

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a slit made by cutting with a saw