Relating to or denoting an allele or chromosomal abnormality which impairs the viability of most of the individuals homozygous for it.
- A chief difficulty in arguing for macroevolution by mutations is the fact that most expressed mutations are either lethal or semi-lethal.
- Some of the genes that gives the mouse its common colours or markings also makes the mouse sick, or unfit to live. These genes are called semi-lethal or lethal.
- Pokey (pok), a sex-linked recessive semi-lethal gene in Tribolium castaneum has been described.
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