(also sickle-cell disease)
A severe hereditary form of anaemia in which a mutated form of haemoglobin distorts the red blood cells into a crescent shape at low oxygen levels. It is commonest among those of African descent.
- Infection can produce severe anaemia and an aplastic crisis in people with sickle-cell anaemia or other abnormalities of haemoglobin.
- In sickle-cell disease, the haemoglobin is abnormal and this causes a change in the shape of the red blood cells.
- The blood condition sickle-cell anaemia is most common in people from Africa, the Caribbean, the eastern Mediterranean, the Middle East and Asia.
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