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- Medicine an indication of a disease detectable by a medical practitioner even if not apparent to the patient: clinical signs of liver diseaseCompare with symptom.
- [mass noun]short for sign language.
- 4 (also zodiacal sign) Astrology each of the twelve equal sections into which the zodiac is divided, named from the constellations formerly situated in each, and associated with successive periods of the year according to the position of the sun on the ecliptic:a sign of the Zodiac a person born under the sign of Virgo
Middle English: from Old French signe (noun), signer (verb), from Latin signum 'mark, token'