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tachyphylaxis

Line breaks: tachy|phyl¦axis
Pronunciation: /ˌtakɪfɪˈlaksɪs
 
/

Definition of tachyphylaxis in English:

noun

[mass noun] Medicine
Rapidly diminishing response to successive doses of a drug, rendering it less effective. The effect is common with drugs acting on the nervous system.
Example sentences
  • Trebling doses of histamine diphosphate were chosen instead of the usual doubling dose because of the half-life of lidocaine, the number of challenges, and the need to minimize possible tachyphylaxis of the histamine effect.
  • The efficacy of calcipotriene is comparable to mid-potency topical corticosteroids; however, it does not cause skin atrophy or tachyphylaxis.
  • This spirometric improvement was maintained throughout the 13-week period without any evidence of tachyphylaxis.

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